Publications
2025
      
      
      
        Federated Knowledge Retrieval Elevates Large Language Model Performance on Biomedical Benchmarks
      
      
      
  
        Cold Spring Harbor Laboratory
         · 
        02 Aug 2025
         · 
        doi:10.1101/2025.08.01.668022
        
        
      
      
        
        
        
      
    
      
      
      
        A Case-Based Explainable Graph Neural Network Framework for Mechanistic Drug Repositioning
      
      
      
  
        Cold Spring Harbor Laboratory
         · 
        02 May 2025
         · 
        doi:10.1101/2025.04.28.651120
        
        
      
      
        
        
        
      
    2024
      
      
      
        Repositioning the Early Pathology of Type 1 Diabetes to the Extraislet Vasculature
      
      
      
  
        The Journal of Immunology
         · 
        01 Mar 2024
         · 
        doi:10.4049/jimmunol.2300769
        
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            PMID: 38426888
          
        
        
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            PMCID: PMC10944819
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Perspectives on tracking data reuse across biodata resources
      
      
      
  
        Bioinformatics Advances
         · 
        01 Jan 2024
         · 
        doi:10.1093/bioadv/vbae057
        
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            PMID: 38721398
          
        
        
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            PMCID: PMC11076920
          
        
      
      
        
        
        
      
    2023
      
      
      
        DrugMechDB: A Curated Database of Drug Mechanisms
      
      
      
  
        Scientific Data
         · 
        16 Sep 2023
         · 
        doi:10.1038/s41597-023-02534-z
        
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            PMID: 37717042
          
        
        
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            PMCID: PMC10505144
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        BioThings Explorer: a query engine for a federated knowledge graph of biomedical APIs
      
      
      
  
        Bioinformatics
         · 
        01 Sep 2023
         · 
        doi:10.1093/bioinformatics/btad570
        
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            PMID: 37707514
          
        
        
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            PMCID: PMC11015316
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Association study between drug prescriptions and Alzheimer’s disease claims in a commercial insurance database
      
      
      
  
        Alzheimer's Research & Therapy
         · 
        24 Jun 2023
         · 
        doi:10.1186/s13195-023-01255-0
        
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            PMID: 37355615
          
        
        
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            PMCID: PMC10290352
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Drug Repurposing using consilience of Knowledge Graph Completion methods
      
      
      
  
        Cold Spring Harbor Laboratory
         · 
        14 May 2023
         · 
        doi:10.1101/2023.05.12.540594
        
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            PMID: 39149283
          
        
        
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            PMCID: PMC11326126
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Schema Playground: a tool for authoring, extending, and using metadata schemas to improve FAIRness of biomedical data
      
      
      
  
        BMC Bioinformatics
         · 
        20 Apr 2023
         · 
        doi:10.1186/s12859-023-05258-4
        
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            PMID: 37081398
          
        
        
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            PMCID: PMC10116472
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        An approach for collaborative development of a federated biomedical knowledge graph-based question-answering system: Question-of-the-Month challenges
      
      
      
  
        Journal of Clinical and Translational Science
         · 
        01 Jan 2023
         · 
        doi:10.1017/cts.2023.619
        
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            PMID: 37900350
          
        
        
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            PMCID: PMC10603356
          
        
      
      
        
        
          
        
        
      
    2022
      
      
      
        Progress toward a universal biomedical data translator
      
      
      
  
        Clinical and Translational Science
         · 
        06 Jun 2022
         · 
        doi:10.1111/cts.13301
        
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            PMID: 35611543
          
        
        
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            PMCID: PMC9372428
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Biolink Model: A universal schema for knowledge graphs in clinical, biomedical, and translational science
      
      
      
  
        Clinical and Translational Science
         · 
        06 Jun 2022
         · 
        doi:10.1111/cts.13302
        
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            PMID: 36125173
          
        
        
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            PMCID: PMC9372416
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Design and application of a knowledge network for automatic prioritization of drug mechanisms
      
      
      
  
        Bioinformatics
         · 
        06 Apr 2022
         · 
        doi:10.1093/bioinformatics/btac205
        
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            PMID: 35561182
          
        
        
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            PMCID: PMC9113361
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Quantitative Metaproteomics and Activity-based Protein Profiling of Patient Fecal Microbiome Identifies Host and Microbial Serine-type Endopeptidase Activity Associated With Ulcerative Colitis
      
      
      
  
        Molecular & Cellular Proteomics
         · 
        01 Mar 2022
         · 
        doi:10.1016/j.mcpro.2022.100197
        
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            PMID: 35033677
          
        
        
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            PMCID: PMC8941213
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        BioThings SDK: a toolkit for building high-performance data APIs in biomedical research
      
      
      
  
        Bioinformatics
         · 
        10 Jan 2022
         · 
        doi:10.1093/bioinformatics/btac017
        
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            PMID: 35020801
          
        
        
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            PMCID: PMC8963279
          
        
      
      
        
        
          
        
        
      
    2021
2020
      
      
      
        Mohawk is a transcription factor that promotes meniscus cell phenotype and tissue repair and reduces osteoarthritis severity
      
      
      
  
        Science Translational Medicine
         · 
        28 Oct 2020
         · 
        doi:10.1126/scitranslmed.aan7967
        
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            PMID: 33115953
          
        
        
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            PMCID: PMC7955769
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Functional Annotation of the Transcriptome of the Pig, Sus scrofa, Based Upon Network Analysis of an RNAseq Transcriptional Atlas
      
      
      
  
        Frontiers in Genetics
         · 
        14 Feb 2020
         · 
        doi:10.3389/fgene.2019.01355
        
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            PMID: 32117413
          
        
        
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            PMCID: PMC7034361
          
        
      
      
        
        
          
        
        
      
    2019
      
      
      
        Time-resolved evaluation of compound repositioning predictions on a text-mined knowledge network
      
      
      
  
        BMC Bioinformatics
         · 
        01 Dec 2019
         · 
        doi:10.1186/s12859-019-3297-0
        
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            PMID: 31829175
          
        
        
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            PMCID: PMC6907279
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Applying citizen science to gene, drug and disease relationship extraction from biomedical abstracts
      
      
      
  
        Bioinformatics
         · 
        03 Sep 2019
         · 
        doi:10.1093/bioinformatics/btz678
        
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            PMID: 31504205
          
        
        
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            PMCID: PMC8104067
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Position β57 of I-A
            g7
            controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset
      
      
      
  
        Science Immunology
         · 
        02 Aug 2019
         · 
        doi:10.1126/sciimmunol.aaw6329
        
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            PMID: 31471352
          
        
        
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            PMCID: PMC6816460
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Aligning Needs: Integrating Citizen Science Efforts into Schools Through Service Requirements.
      
      
      
  
        Human Computation
         · 
        02 Jun 2019
         · 
        doi:10.15346/hc.v6i1.4
        
        
      
      
        
        
          
        
        
      
    2018
      
      
      
        Using single cell analysis for translational studies in immune mediated diseases: Opportunities and challenges
      
      
      
  
        Molecular Immunology
         · 
        01 Nov 2018
         · 
        doi:10.1016/j.molimm.2018.09.020
        
           · 
          
            PMID: 30300798
          
        
        
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            PMCID: PMC6258053
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis
      
      
      
  
        Osteoarthritis and Cartilage
         · 
        01 Nov 2018
         · 
        doi:10.1016/j.joca.2018.07.012
        
           · 
          
            PMID: 30081074
          
        
        
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            PMCID: PMC6245598
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Association study of long-term kidney transplant rejection using whole-exome sequencing
      
      
      
  
        Cold Spring Harbor Laboratory
         · 
        16 Oct 2018
         · 
        doi:10.1101/444497
        
        
      
      
        
        
          
        
        
      
    
      
      
      
        The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis
      
      
      
  
        Proceedings of the National Academy of Sciences
         · 
        03 Oct 2018
         · 
        doi:10.1073/pnas.1810137115
        
           · 
          
            PMID: 30282735
          
        
        
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            PMCID: PMC6196526
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        The Healthy Pregnancy Research Program: transforming pregnancy research through a ResearchKit app
      
      
      
  
        npj Digital Medicine
         · 
        05 Sep 2018
         · 
        doi:10.1038/s41746-018-0052-2
        
           · 
          
            PMID: 31304325
          
        
        
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            PMCID: PMC6550256
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Triflic acid treatment enables LC-MS/MS analysis of insoluble bacterial biomass
      
      
      
  
        Cold Spring Harbor Laboratory
         · 
        11 Jul 2018
         · 
        doi:10.1101/367599
        
        
      
      
        
        
          
        
        
      
    
      
      
      
        Exploring applications of crowdsourcing to cryo-EM
      
      
      
  
        Journal of Structural Biology
         · 
        01 Jul 2018
         · 
        doi:10.1016/j.jsb.2018.02.006
        
           · 
          
            PMID: 29486249
          
        
        
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            PMCID: PMC6086358
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis
      
      
      
  
        Science Translational Medicine
         · 
        14 Feb 2018
         · 
        doi:10.1126/scitranslmed.aan0746
        
           · 
          
            PMID: 29444976
          
        
        
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            PMCID: PMC6204214
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Cross-linking BioThings APIs through JSON-LD to facilitate knowledge exploration
      
      
      
  
        BMC Bioinformatics
         · 
        01 Feb 2018
         · 
        doi:10.1186/s12859-018-2041-5
        
           · 
          
            PMID: 29390967
          
        
        
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            PMCID: PMC5796402
          
        
      
      
        
        
          
        
        
      
    2017
      
      
      
        Science Game Lab: tool for the unification of biomedical games with a purpose
      
      
      
  
        Cold Spring Harbor Laboratory
         · 
        10 Jul 2017
         · 
        doi:10.1101/156141
        
        
      
      
        
        
          
        
        
      
    
      
      
      
        Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes
      
      
      
  
        Osteoarthritis and Cartilage
         · 
        01 Jun 2017
         · 
        doi:10.1016/j.joca.2016.11.007
        
           · 
          
            PMID: 27884645
          
        
        
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            PMCID: PMC5438901
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        EXPLANe: An Extensible Framework for Poster Annotation with Mobile Devices
      
      
      
  
        Cold Spring Harbor Laboratory
         · 
        29 Mar 2017
         · 
        doi:10.1101/121178
        
        
      
      
        
        
          
        
        
      
    
      
      
      
        Quantitative Metaproteomics and Activity-Based Probe Enrichment Reveals Significant Alterations in Protein Expression from a Mouse Model of Inflammatory Bowel Disease
      
      
      
  
        Journal of Proteome Research
         · 
        23 Jan 2017
         · 
        doi:10.1021/acs.jproteome.6b00938
        
           · 
          
            PMID: 28052195
          
        
        
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            PMCID: PMC5441882
          
        
      
      
        
        
          
        
        
      
    2016
      
      
      
        Citizen Science for Mining the Biomedical Literature
      
      
      
  
        Citizen Science: Theory and Practice
         · 
        31 Dec 2016
         · 
        doi:10.5334/cstp.56
        
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            PMID: 30416754
          
        
        
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            PMCID: PMC6226017
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy
      
      
      
  
        Osteoarthritis and Cartilage
         · 
        01 Sep 2016
         · 
        doi:10.1016/j.joca.2016.04.015
        
           · 
          
            PMID: 27118398
          
        
        
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            PMCID: PMC4992644
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Data-Driven Approach To Determine Popular Proteins for Targeted Proteomics Translation of Six Organ Systems
      
      
      
  
        Journal of Proteome Research
         · 
        19 Jul 2016
         · 
        doi:10.1021/acs.jproteome.6b00095
        
           · 
          
            PMID: 27356587
          
        
        
           · 
          
            PMCID: PMC5120959
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate With Worse Long‐Term Outcomes
      
      
      
  
        American Journal of Transplantation
         · 
        01 Jul 2016
         · 
        doi:10.1111/ajt.13728
        
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            PMID: 26990570
          
        
        
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            PMCID: PMC5501990
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        YY1 plays an essential role at all stages of B-cell differentiation
      
      
      
  
        Proceedings of the National Academy of Sciences
         · 
        22 Jun 2016
         · 
        doi:10.1073/pnas.1606297113
        
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            PMID: 27335461
          
        
        
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            PMCID: PMC4941496
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Extending gene ontology in the context of extracellular RNA and vesicle communication
      
      
      
  
        Journal of Biomedical Semantics
         · 
        12 Apr 2016
         · 
        doi:10.1186/s13326-016-0061-5
        
           · 
          
            PMID: 27076901
          
        
        
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            PMCID: PMC4830068
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Branch: an interactive, web-based tool for testing hypotheses and developing predictive models
      
      
      
  
        Bioinformatics
         · 
        07 Mar 2016
         · 
        doi:10.1093/bioinformatics/btw117
        
           · 
          
            PMID: 27153723
          
        
        
           · 
          
            PMCID: PMC4920125
          
        
      
      
        
        
          
        
        
      
    2015
      
      
      
        Prioritizing Proteomics Assay Development for Clinical Translation
      
      
      
  
        Journal of the American College of Cardiology
         · 
        01 Jul 2015
         · 
        doi:10.1016/j.jacc.2015.04.072
        
           · 
          
            PMID: 26160638
          
        
        
      
      
        
        
          
        
        
      
    
      
      
      
        OncoRep: an n-of-1 reporting tool to support genome-guided treatment for breast cancer patients using RNA-sequencing
      
      
      
  
        BMC Medical Genomics
         · 
        21 May 2015
         · 
        doi:10.1186/s12920-015-0095-z
        
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            PMID: 25989980
          
        
        
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            PMCID: PMC4494802
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors
      
      
      
  
        Science Translational Medicine
         · 
        13 May 2015
         · 
        doi:10.1126/scitranslmed.3009986
        
           · 
          
            PMID: 25972004
          
        
        
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            PMCID: PMC5018401
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Crowdsourcing in biomedicine: challenges and opportunities
      
      
      
  
        Briefings in Bioinformatics
         · 
        17 Apr 2015
         · 
        doi:10.1093/bib/bbv021
        
           · 
          
            PMID: 25888696
          
        
        
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            PMCID: PMC4719068
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Omics Pipe: a community-based framework for reproducible multi-omics data analysis
      
      
      
  
        Bioinformatics
         · 
        30 Jan 2015
         · 
        doi:10.1093/bioinformatics/btv061
        
           · 
          
            PMID: 25637560
          
        
        
           · 
          
            PMCID: PMC4443682
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Integration of extracellular RNA profiling data using metadata, biomedical ontologies and Linked Data technologies
      
      
      
  
        Journal of Extracellular Vesicles
         · 
        01 Jan 2015
         · 
        doi:10.3402/jev.v4.27497
        
           · 
          
            PMID: 26320941
          
        
        
           · 
          
            PMCID: PMC4553261
          
        
      
      
        
        
          
        
        
      
    2014
      
      
      
        MICROTASK CROWDSOURCING FOR DISEASE MENTION ANNOTATION IN PUBMED ABSTRACTS
      
      
      
  
        Biocomputing 2015
         · 
        01 Nov 2014
         · 
        doi:10.1142/9789814644730_0028
        
        
      
      
        
        
          
        
        
      
    
      
      
      
        CROWDSOURCING AND MINING CROWD DATA
      
      
      
  
        Biocomputing 2015
         · 
        01 Nov 2014
         · 
        doi:10.1142/9789814644730_0026
        
        
      
      
        
        
          
        
        
      
    
      
      
      
        Oxidative Stress Diverts tRNA Synthetase to Nucleus for Protection against DNA Damage
      
      
      
  
        Molecular Cell
         · 
        01 Oct 2014
         · 
        doi:10.1016/j.molcel.2014.09.006
        
           · 
          
            PMID: 25284223
          
        
        
           · 
          
            PMCID: PMC4224670
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        MyGene.info: gene annotation query as a service
      
      
      
  
        Cold Spring Harbor Laboratory
         · 
        18 Sep 2014
         · 
        doi:10.1101/009332
        
        
      
      
        
        
          
        
        
      
    
      
      
      
        Functional expression of dental plaque microbiota
      
      
      
  
        Frontiers in Cellular and Infection Microbiology
         · 
        14 Aug 2014
         · 
        doi:10.3389/fcimb.2014.00108
        
           · 
          
            PMID: 25177549
          
        
        
           · 
          
            PMCID: PMC4132376
          
        
      
      
        
        
          
        
        
      
    2013
      
      
      
        Ten Simple Rules for Cultivating Open Science and Collaborative R&D
      
      
      
  
        PLoS Computational Biology
         · 
        26 Sep 2013
         · 
        doi:10.1371/journal.pcbi.1003244
        
           · 
          
            PMID: 24086123
          
        
        
           · 
          
            PMCID: PMC3784487
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Deep Sequencing of the Murine Igh Repertoire Reveals Complex Regulation of Nonrandom V Gene Rearrangement Frequencies
      
      
      
  
        The Journal of Immunology
         · 
        01 Sep 2013
         · 
        doi:10.4049/jimmunol.1301279
        
           · 
          
            PMID: 23898036
          
        
        
           · 
          
            PMCID: PMC3778908
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Unifying model for molecular determinants of the preselection Vβ repertoire
      
      
      
  
        Proceedings of the National Academy of Sciences
         · 
        05 Aug 2013
         · 
        doi:10.1073/pnas.1304048110
        
           · 
          
            PMID: 23918392
          
        
        
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            PMCID: PMC3752219
          
        
      
      
        
        
          
        
        
      
    
      
      
      
        Crowdsourcing for bioinformatics
      
      
      
  
        Bioinformatics
         · 
        19 Jun 2013
         · 
        doi:10.1093/bioinformatics/btt333
        
           · 
          
            PMID: 23782614
          
        
        
           · 
          
            PMCID: PMC3722523
          
        
      
      
        
        
          
        
        
      
    2012
      
      
      
        genegames.org: High-Throughput Access to Biological Knowledge and Reasoning through Online Games
      
      
      
  
        2012 IEEE Second International Conference on Healthcare Informatics, Imaging and Systems Biology
         · 
        01 Sep 2012
         · 
        doi:10.1109/HISB.2012.70
        
        
      
      
        
        
          
        
        
      
    2011
      
      
      
        TCLUST: A Fast Method for Clustering Genome-Scale Expression Data
      
      
      
  
        IEEE/ACM Transactions on Computational Biology and Bioinformatics
         · 
        01 May 2011
         · 
        doi:10.1109/TCBB.2010.34
        
           · 
          
            PMID: 20479508
          
        
        
      
      
        
        
          
        
        
      
    2010
      
      
      
        Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency
      
      
      
  
        Proceedings of the National Academy of Sciences
         · 
        23 Feb 2010
         · 
        doi:10.1073/pnas.0914019107
        
           · 
          
            PMID: 20133595
          
        
        
           · 
          
            PMCID: PMC2840467
          
        
      
      
        
        
          
        
        
      
    2009
2008
2007
2006
      
      
      
        Reply to “Normalization procedures and detection of linkage signal in genetical-genomics experiments”
      
      
      
  
        Nature Genetics
         · 
        01 Aug 2006
         · 
        doi:10.1038/ng0806-856
        
        
      
      
        
        
          
        
        
      
    
      
      
      
        An efficient rapid system for profiling the cellular activities of molecular libraries
      
      
      
  
        Proceedings of the National Academy of Sciences
         · 
        21 Feb 2006
         · 
        doi:10.1073/pnas.0511292103
        
           · 
          
            PMID: 16492761
          
        
        
           · 
          
            PMCID: PMC1413928
          
        
      
      
        
        
          
        
        
      
    2005
2004
2003
      
      
      
        Genome-Wide Analysis of CREB Target Genes Reveals A Core Promoter Requirement for cAMP Responsiveness
      
      
      
  
        Molecular Cell
         · 
        01 May 2003
         · 
        doi:10.1016/S1097-2765(03)00199-0
        
        
      
      
        
        
          
        
        
      
    2002
      
      
      
        Large Scale Molecular Analysis Identifies Genes with Altered Expression in Salivary Adenoid Cystic Carcinoma
      
      
      
  
        The American Journal of Pathology
         · 
        01 Oct 2002
         · 
        doi:10.1016/S0002-9440(10)64408-2
        
           · 
          
            PMID: 12368205
          
        
        
      
      
        
        
          
        
        
      
    2001
2000
      
      
      
        Docking molecules by families to increase the diversity of hits in database screens: Computational strategy and experimental evaluation
      
      
      
  
        Proteins: Structure, Function, and Genetics
         · 
        01 Jan 2000
         · 
        doi:10.1002/1097-0134(20010201)42:2<279::AID-PROT150>3.0.CO;2-U
        
           · 
          
            PMID: 11119652