Distribution of GO annotations among human genes

Recently, someone emailed me to ask how I got the data behind this figure that I often use in the introductions of my talks: This figure shows that while there are few genes that are very well annotated (100s of GO annotations manually annotated by biocurators), that...

Twenty questions for genes

Part 1: Introduction to the concept (this post) Part 2: The prototype game Part 3: Evaluation framework If I asked you to think of your favorite gene, do you think I could guess the identity of that gene by first asking you twenty yes / no questions? I personally...