Be Thankful for the Little Things… — #GeneOTW with DICER1

Be Thankful for the Little Things… and the big things that make the little things work  I’ve said it before: small things can make a big difference.  This Thanksgiving (and every day), it’s important that we remember and give thanks for the little things.  The little things, like microRNAs (miRNAs). miRNAs are small, non-coding RNAs that are important for the inhibition of gene...
read more

The Double Life of FAS – #GeneOTW

1989 was an important year.  In May of 1989, Yonehara et al. published a report that treatment with an anti-FAS antibody leads to the death of cells expressing our ominously-named gene-of-the-week, “Fas cell surface death receptor” (FAS).1 In July of 1989, Bernhard Trauth and other members of Dr. Peter H. Krammer’s lab described “apoptosis antigen 1” (APO-1) that, when bound by a monoclonal...
read more

How to Target a Tumor’s Infrastructure — #GeneOTW with RHBDF1

America is failing. Or rather… our infrastructure is.  According to the American Society of Civil Engineers, the condition and performance of our infrastructure is so poor, that we failed their “2013 Report Card” with a resounding grade of D+.1  Besides being embarrassing, it’s potentially dangerous; California alone contains 2,978 deficient bridges and 807 high hazard dams!2  In fact, nearly...
read more

Got Lactoferrin? — #GeneOTW

Despite declining birth and fertility rates,1 the global market for baby food and infant formula is on the rise; with a projected increase to $31 billion by 2020,2 worldwide spending on baby food products will soon exceed the total annual budget for NIH research grants!   Much of this industry growth can be attributed to increasing demand for advanced nutrition, including supplements that...
read more

Why’s it gotta be so complicated? — #GeneOTW with HER2

Last week, Melissa discussed the use of aspirin as a preventative measure against colorectal cancer.  While the risks may outweigh the benefits for the general population, aspirin may be a useful treatment in specific populations (e.g., those with high levels of HPGD).  So, if you knew that you had high HPGD, would you take more aspirin?  Or if you have already been diagnosed with cancer—a...
read more

Does an Aspirin a Day Keep Cancer Away? — #GeneOTW with PTGS2

With over 100 billion tablets produced (and consumed) yearly,1 aspirin has come a long way from its humble beginnings as the active ingredient in willow bark—a medicinal remedy used since ancient times, by the likes of Hippocrates and Pliny the Elder.  Since its first patented formulation in 1897, aspirin has been heralded as a Wonder Drug, has provided the foundation for Nobel Prize-winning...
read more