How to Target a Tumor’s Infrastructure — #GeneOTW with RHBDF1

America is failing. Or rather… our infrastructure is.  According to the American Society of Civil Engineers, the condition and performance of our infrastructure is so poor, that we failed their “2013 Report Card” with a resounding grade of D+.1  Besides being embarrassing, it’s potentially dangerous; California alone contains 2,978 deficient bridges and 807 high hazard dams!2  In fact, nearly...
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Why’s it gotta be so complicated? — #GeneOTW with HER2

Last week, Melissa discussed the use of aspirin as a preventative measure against colorectal cancer.  While the risks may outweigh the benefits for the general population, aspirin may be a useful treatment in specific populations (e.g., those with high levels of HPGD).  So, if you knew that you had high HPGD, would you take more aspirin?  Or if you have already been diagnosed with cancer—a...
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The Cure at Salk Cancer Day Symposium

Karthik G. and I will be presenting a poster tomorrow at the Salk Institute's Cancer Day Symposium.  We will be presenting data from a year with the scientific discovery game The Cure.  You can read more about those results on the arXiv.If you are coming, please stop by for a chat!  We would especially love the chance to discuss the new, collaborative decision tree-building...
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The Cure at Salk Cancer Day Symposium

Karthik G. and I will be presenting a poster tomorrow at the Salk Institute's Cancer Day Symposium.  We will be presenting data from a year with the scientific discovery game The Cure.  You can read more about those results on the arXiv.If you are coming, please stop by for a chat!  We would especially love the chance to discuss the new, collaborative decision tree-building...
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NIH Grant proposal for sale!

Last November, Andrew and I submitted an R21 proposal for consideration by the NIH.  Today, we received the summary statement.  Since a lot of work went into writing it, I feel compelled to share it regardless of whether its ever funded (which currently seems like a longshot, but you never know).   Perhaps someone will find a useful idea in there and the world will somehow be...
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The Network of BioThings

I offer an idea, and a proposal… What: We want to structure biological knowledge by annotating BioThings (genes, proteins, mutations, diseases, and drugs) in biomedical research articles. We want to comprehensively annotate the mentions of these BioThings in research articles, and also want to describe the nature of the relationships between these entities. Finally, we want to do it in...
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