BioGPS has become the valuable resource that it is because of the contributions from our wonderful user community. Thank you for contributing plugins, suggestions, and ideas–all of which have improved BioGPS for everyone. In order to celebrate the contributions of BioGPS users to the scientific research community, this series will feature publications and articles generated by BioGPS users. When long time users of BioGPS like Dr. Charles Farber publish so much interesting work using BioGPS, we can’t help but to want to know more about the researcher and the research team themselves. Hence, in this week’s post we will be introducing the BioGPS featured Researcher series–an extension of the Featured Article series. We sincerely hope you will join us in celebrating the fascinating work that YOU do.
This week, we will be featuring a very productive research group and long time user of BioGPS: Dr. Eric Schirmer’s group from the Wellcome Trust Centre for Cell Biology at the University of Edinburgh. Dr. Schirmer’s group studies nuclear envelope proteins and how mutations in these proteins can lead to the development of tissue-specific pathologies such as muscular dystrophy, neuropathy, lipodystrophy and symptoms of progeria.
Dr. Eric Schirmer kindly answered our inquiries for this series.
- How did the team learn about BioGPS??
We got onto BioGPS back before it became generally available with a password from the Hogenesch lab.
- How does your team utilize BioGPS in this research?.
We have analyzed the nuclear envelope proteome from several different tissues and used BioGPS to compare with our proteomics results.Other research published using BioGPS:
- Tissue specificity in the nuclear envelope supports its functional complexity. de Las Heras JI, Meinke P, Batrakou DG, Srsen V, Zuleger N, Kerr AR, Schirmer EC. Nucleus. 2013 Nov-Dec;4(6):460-77. doi: 10.4161/nucl.26872. Epub 2013 Nov 8. Review.
- The nuclear envelope proteome differs notably between tissues. Korfali N, Wilkie GS, Swanson SK, Srsen V, de Las Heras J, Batrakou DG, Malik P, Zuleger N, Kerr AR, Florens L, Schirmer EC. Nucleus. 2012 Nov-Dec;3(6):552-64. doi: 10.4161/nucl.22257. Epub 2012 Sep 18.
- Several novel nuclear envelope transmembrane proteins identified in skeletal muscle have cytoskeletal associations.Wilkie GS, Korfali N, Swanson SK, Malik P, Srsen V, Batrakou DG, de las Heras J, Zuleger N, Kerr AR, Florens L, Schirmer EC. Mol Cell Proteomics. 2011 Jan;10(1):M110.003129. doi: 10.1074/mcp.M110.003129. Epub 2010 Sep 27.
- The leukocyte nuclear envelope proteome varies with cell activation and contains novel transmembrane proteins that affect genome architecture.Korfali N, Wilkie GS, Swanson SK, Srsen V, Batrakou DG, Fairley EA, Malik P, Zuleger N, Goncharevich A, de Las Heras J, Kelly DA, Kerr AR, Florens L, Schirmer EC. Mol Cell Proteomics. 2010 Dec;9(12):2571-85. doi: 10.1074/mcp.M110.002915. Epub 2010 Aug 6.
- Cell-specific and lamin-dependent targeting of novel transmembrane proteins in the nuclear envelope. Malik P1, Korfali N, Srsen V, Lazou V, Batrakou DG, Zuleger N, Kavanagh DM, Wilkie GS, Goldberg MW, Schirmer EC. Cell Mol Life Sci. 2010 Apr;67(8):1353-69. doi: 10.1007/s00018-010-0257-2. Epub 2010 Jan 21.
Thanks again to Dr. Eric C Schirmer for answering our questions. Click here to learn more about Dr. Eric Schirmer and the fascinating research his group does.
Used BioGPS and cited it in your publication? Let us know! We would love to feature YOUR work, no matter how long ago it was published. BioGPS Featured Article Series only started recently, but we know your contributions to science is ongoing.
2016.06.16 – Links in this post updated to lead to original articles, rather than PMC archived versions.