BioGPS Featured Article – Molecular signatures of the evolving immune response in mice with bordetella pertussis infection

BioGPS has become the valuable resource that it is because of the contributions from our wonderful user community. Thank you for contributing plugins, suggestions, and ideas–all of which have improved BioGPS for everyone. In order to celebrate the contributions of BioGPS users to the scientific research community, this series will feature publications and articles generated by BioGPS users. We sincerely hope you will join us in celebrating the fascinating work that YOU do.

To kick off the series, we will feature an article that was published less than two weeks ago:
Molecular Signatures of the Evolving Immune Response in Mice following a Bordetella pertussis Infection by René H. M. Raeven, Jolanda Brummelman, Jeroen L. A. Pennings, Olaf E. M. Nijst, Betsy Kuipers, Laura E. R. Blok, Kina Helm, Elly van Riet, Wim Jiskoot, Cecile A. C. M. van Els, Wanda G. H. Han, Gideon F. A. Kersten, and Bernard Metz.(DOI 10.1371/journal.pone.0104548

The first author of the article, René H. M. Raeven, kindly answered our inquiries for this series.

  1. Who is the team behind the work that was published in Molecular Signatures of the Evolving Immune Response in Mice following a Bordetella pertussis Infection?
    Intravacc conducted this study in collaboration with the National Institute for Public Health and the Environment (RIVM), and the Leiden Academic Centre for Drug Research all located in The Netherlands.
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  3. Please provide a brief summary (200 words or less) of your research findings from Molecular Signatures of the Evolving Immune Response in Mice following a Bordetella pertussis Infection.
    Worldwide resurgence of pertussis necessitates the need for improvement of pertussis vaccines and vaccination strategies. The purpose of this study was to dissect the immune response after experimental Bordetella pertussis infection in mice. Data were collected from (i) microarray, flow cytometry, multiplex immunoassays, and bacterial clearance; (ii) twelve time points during the infection; and (iii) tissues involved in the immune responses, i.e. lungs, spleen and blood. Combined data revealed detailed insight in molecular and cellular sequence of events connecting different phases (innate, bridging and adaptive) of the immune response following the infection. BioGPS was implemented to identify the influx, presence or activation of particular immunological cells in the lungs and spleen. Activation of specific cell markers provided insight into the transition from innate towards adaptive immune responses. Signatures preceding the local generation of Th1 and Th17 cells as well as IgA in the lungs, considered key elements in protection against Bordetella pertussis, were established. The results may provide guidance in selecting new vaccine candidates that should evoke local and prolonged protective immune responses.
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  5. How did the team learn about and/or utilize BioGPS for this research?
    BioGPS was previously used by Jeroen Pennings, co-author on this publication
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  7. What are some future directions for the team behind this research?
    The established signatures and methodology from this study will be further implemented into pertussis vaccine research

 

Thanks again to René H. M. Raeven for answering our questions. Click here to read their fascinating article. It’s worth a look because these awesome researchers have made their work open access, so you can read the whole exciting article for free!

Used BioGPS and cited it in your publication? Let us know! We would love to feature YOUR work, no matter how long ago it was published. BioGPS Featured Article Series only started recently, but we know your contributions to science is ongoing.


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